Immunotherapy with immune checkpoint inhibitors is standard first-line treatment for advanced renal cell carcinoma (RCC), but ...
Validated Assay Can Test for Interferon Activity in Pediatric Inflammatory Diseases Using Biomarkers
The assay is fast and simple and has already shown clinical utility, although its interpretation may be limited by reference ...
CytomX Therapeutics announced initial translational biomarker data from its ongoing Phase 1 study of CX-801 in advanced melanoma, highlighting tumor-selective activation of interferon signaling and ...
The regulation of type I interferon (IFN-1) signaling is crucial for fine-tuning the innate immune response to combat pathogens, fight cancer and prevent autoimmune diseases. Disrupted IFN-1 signaling ...
Higher baseline expression of interferon (IFN)-driven genes was tied to a better response to methotrexate in patients with juvenile idiopathic arthritis (JIA). Gene enrichment in the IFN-alpha (type I ...
Myeloid cells mediate interferon-driven resistance to immunotherapy inadvanced renal cell carcinomaPublication: Immunity - ...
Data supportive of CX-801’s mechanism of action and the ongoing Phase 1 combination study with KEYTRUDA® (pembrolizumab) - SOUTH SAN FRANCISCO, Calif., Nov. 04, 2025 (GLOBE NEWSWIRE) -- CytomX ...
Inspired by a rare immune disorder, researchers headed by a team at Columbia University have created an antiviral with an mRNA delivery system that displays broad activity against Zika virus, SARS-CoV ...
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