Nature

Signalling Pathways of Innate Immunity

The innate immune system serves as the body's first line of defence, rapidly detecting and responding to external pathogens and internal damage. Recent advances in the field have highlighted the ...
eLife

Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity

Hematopoietic reprogramming reflects the selective and evolutionarily conserved engagement of transcription factor networks that encode innate immune memory in long-lived stem cells.
科学技術振興機構

[Toshiyuki Shimizu] Structural analyses of Toll-like receptors sensing single stranded nucleic acids in innate immunity and their application

Higher organisms have an immune system for eliminating pathogens to protect themselves. The immune system is composed of two major subdivisions, innate immunity and adaptive immunity. Both systems ...
Medical Herald

How ALV-J Virus Bypasses Immune Defense Using miR-155

Researchers uncover that ALV-J boosts miR-155 to suppress TRAF3 and STAT1, weakening immune responses and promoting viral ...
eLife

Herbivorous insects independently evolved salivary effectors to regulate plant immunity by destabilizing the malectin-LRR RLP NtRLP4

State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Zhejiang Key Laboratory of Green Plant Protection, Institute of Plant ...
科学技術振興機構

Research Results

The 2011 Nobel Prize in Physiology or Medicine was awarded to 3 researchers in the field of immunology: French molecular biologist Jules A. Hoffmann, Bruce Alan Beutler of the Scripps Research ...