The Indianapolis Colts are hosting the Tennessee Titans on Oct. 26, 2025, in NFL Week 8 action. Will the Lucas Oil Stadium roof be open?

Indianapolis is a 14.5-point favorite in the latest Titans vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 47.5. Before making any Colts vs. Titans picks, make sure you check out the NFL picks from the SportsLine Projection Model.

Former Duke Blue Devil Daniel Jones, whom the Colts signed to a one-year deal over the offseason, entered Sunday ranked fifth with 1,790 passing yards and second with an 80.4 ESPN QBR. He also has 10 touchdown tosses against three interceptions as well as 83 rushing yards and four scores on 29 carries.

Daniel Jones threw for 288 yards and two touchdowns as the Indianapolis Colts beat the Los Angeles Chargers 38-24.

These three potential outcomes could sway the game in favor of the Indianapolis Colts vs. the Tennessee Titans.

Indianapolis Colts quarterback Anthony Richardson had surgery earlier this week on the orbital fracture he suffered prior to the Arizona game, according to Ian Rapoport. Richardson was placed on injured reserve the day after the Arizona game. Rapoport added that there's a chance Richardson could return this season.