Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs) that affects mostly the elderly (median age of 70 years). MDS is characterized by two clinical manifestations: (i ...

The field of DNA microarray data analysis is getting increasingly complicated as scientists develop new array technologies and analysis algorithms, yet accurate introductory information on the subject ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Two of the critical issues that arise when examining DNA microarray data are (1) determination of which genes best discriminate among the different types of tissue, and (2) characterization of ...

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies. In a study published in the ...

The human genome project was undertaken to determine the human DNA sequence and analyze variation among individuals. To make use of this information, tools were developed that could collect and ...

DNA microarray analysis showed that a new mouse line developed by Kumamoto University in Japan has altered gene sets similar to those altered in human COPD patients.

Would you want to know if your unborn baby is at risk of autism? Researchers wrapping up a 4,406-patient study say that a new genetic test that analyzes fetal DNA in more detail than current prenatal ...

Should sentinel node biopsy (SNB) be restricted to breast cancer-dedicated surgeons? A single institution prospective trial No significant financial relationships to disclose. This is an ASCO Meeting ...

Pat Brown, CEO of Impossible Foods (CA, USA) and professor emeritus in the department of biochemistry at Stanford University (CA, USA), takes us through the invention of DNA microarrays, their ...

Advancements in technologies have revolutionized the genetic landscape. Chromosomal microarray analysis (CMA) becomes a proven method and is implemented to detect gains and losses of DNA and absence ...

A dose finding followed by a phase II study of oral UFT (uracil/tegafur) and lv (leucovorin) plus i.v. mitomycin (MMC) in patients (pts) with metastatic colorectal cancer (MCRC): Phase I results No ...