The farnesoid X receptor (FXR), a bile acid receptor, plays a direct role regulating innate immune cells in the gut, and treating mice with an FXR agonist improved symptoms of inflammatory bowel ...

Innate immunity constitutes the body’s first line of defence against invading pathogens. This ancient, evolutionarily conserved system is activated within minutes of encountering foreign agents, ...

The complement component C5a and its receptors, C5aR1 and C5aR2, are central to the orchestration of innate immunity. C5a is a potent anaphylatoxin generated during complement activation, acting as a ...

Activates innate and adaptive immune pathways, including increased antigen-experienced CD8 + T cells, activated CD4 + T cells, and Ki67 + NK cells. Induces immune-regulating chemokines CXCL9 and ...

RIDE-001, a first-in-class nanomedicine, effectively trained myeloid progenitor cells to elicit myeloid-driven anticancer innate immune responses, as demonstrated in preclinical studies across ...

Filoviruses are negative-sense and single-stranded ribonucleic acid (RNA) viruses. The most well-known human-infecting filoviruses are marburgviruses and ebolaviruses. Infection can result in ...

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring ...

Saliva and oral cells are important routes for transmission and infection by the novel coronavirus COVID-19. Researchers hypothesized that the body's innate immune system may protect against ...

Researchers have uncovered how the brain’s immune cells, called microglia, can act as protectors rather than destroyers in Alzheimer’s disease.

A study published in Immunity by physician-scientist Read Pukkila-Worley, MD, and MD/PhD students Nicholas D. Peterson and Samantha Y. Tse describes a new manner of detecting microbial infection that ...