Purdy was on the 49ers’ sideline in a road game for the first time since re-aggravating his toe injury against the Jaguars.

The San Francisco 49ers have already lost linebacker Fred Warner to a long-term injury, and now they may have lost another ...

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost ...

The NFL season continues when the Houston Texans host the San Francisco 49ers Sunday. Start time, how to watch, streaming and ...

The San Francisco 49ers have somehow managed to enter Week 8 with an opportunity to stay atop the NFC West with a win over a ...

The second-lowest projected scoring total of the NFL’s Week 8 schedule belongs to the San Francisco 49ers and Houston Texans ...

Catch the San Francisco 49ers take on the Houston Texans on Sunday, October 26. Here's everything you need to know about how ...

Down 16-0, the 49ers came alive with last-minute theatrics before halftime, highlighted by Kittle’s 17-yard, third-down ...

Two teams on opposite sides of the NFL standings will square off in a Week 8 matchup. The first seven weeks of the NFL season ...

For the first time in nearly a year, the 49ers defense has notched an interception, ending an NFL record-long drought.

Texans head coach DeMeco Ryans is a former 49ers defensive coordinator under Kyle Shanahan, so San Francisco knows how ...